A Preliminary
View on Some Genetic Aspects of Irritable Bowel Syndrome with Regards to
Neuropsychiatric Manifestations
Gabriel Luta1, Radu Lefter2, Alin Ciobica1,2,3,
Ioana Miruna Balmus4*, Ioannis Mavroudis5,6*, Sorin
Cristian Cimpeanu1, Mirela Cimpeanu1
1Department of Biology, Faculty of Biology, Alexandru
Ioan Cuza University, B dul Carol I, no 11, Iasi,
Romania
2Center of Biomedical Research, Romanian Academy, Iasi,
B dul Carol I, no 8, Romania
3Academy of Romanian Scientists, Splaiul
Independentei nr. 54, sector 5, 050094 Bucuresti, Romania
4Department of Exact Sciences and Natural Sciences,
Institute of Interdisciplinary Research, Alexandru Ioan Cuza University of
Iasi, Alexandru Lăpușneanu Street, no. 26,
700057, Iași, Romania
5Laboratory of Neuropathology, Electron Microscopy
First Department of Neurology, Aristotle University, 54124 Thessaloniki, Greece
6Leeds Teaching Hospitals, Leeds LS97TF, UK
*Correspondance: i.mavroudis@nhs.net,
balmus.ioanamiruna@yahoo.com
Abstract. Since
the newest functional gastrointestinal disorders diagnostic criteria (ROME IV),
the formely functional bowel disorder irritable bowel syndrome (IBS) is
currently known as a common chronic disorder of the brain gut interaction.
The main clinical symptomatology including abdominal pain, discomfort, and
altered gastrointestinal motility, as well as the absence of any organic
impairment or significant histological changes led to the confirmed hypothesis
of multicomponent pathology and multifactorial etiogenesis. Thus, considering
our previous experience in this area of research, this mini-review aimed to
present a preliminary view of the possible genetic component underlying or
predisposing to neurolopsychiatric and gastrointestinal impairments co-ocurring
in IBS.
Key words: irritable bowel
syndrome, affective disorders, anxiety, depression, polymorphisms, genetic
predisposition
DOI https://doi.org/10.56082/annalsarscibio.2022.1.104
